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Guidance on Detailed Message Structure and the Use of Specific LOINC Codes

This document contains best practice recommendations from AIRA’s SISC and the CDC on how to structure and populate VXU and RSP messages using specific LOINC codes to include observations such as patient immunity, refusals, indications/contraindications and a...

Guidance on Indicating Clinical Trial Vaccines

Vaccination events that occur as part of clinical trial can be reported to IIS under pre-defined circumstances. This guidance document provides an HL7 method to indicate the vaccination event was part of a clinical trial. It also provides additional considerat...

Guidance on Indicating Preferable and Contraindicated Vaccines

This document outlines an approach to specify preferred or contraindicated vaccine types in a response message

Guidance on Messaging Preferred Name of Patient

Gender-marginalized individuals face significant barriers to adequate and culturally responsive health care, leading to numerous health disparities. The preferred name is the name that should be used when addressing or referencing the patient. For the purposes...

Guidance on Populating OBX-14

Guidance on Populating OBX-14

Issued on September 6, 2019 by AIRA

This document provides guidance on how to populate OBX-14 for common observation types

Guidance on Unit of Sale/Unit of Use Lot Numbers

Guidance on Unit of Sale/Unit of Use Lot Numbers

Issued on June 14, 2018 by AIRA, CDC

This guidance clarifies the process and sets expectations for management of varied vaccine lot numbers, and shares the results of a survey of vaccine manufacturers regarding their practices in assigning Unit of Sale and Unit of Use lot numbers using a pattern,...

Handling IIS Opt-Outs

Handling IIS Opt-Outs

Issued on July 22, 2021 by AIRA

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AIRA sent out an Information Request to the membership to gather the collective expertise of the IIS community regarding handling IIS Opt-Outs

Hands-On with IIS Training Solutions & Workforce Development

Hands-On with IIS Training Solutions & Workforce Development

Issued on April 24, 2017 by CDC, PHII, Intellix Solutions LLC

National Meeting Presentation | Hands-On with IIS Training Solutions & Workforce Development

Harnessing Electronic Clinical Data to Report Adult and Prenatal Immunization Quality Measures

Harnessing Electronic Clinical Data to Report Adult and Prenatal Immunization Quality Measures

Issued on July 19, 2021 by Journal of the American Medical Informatics Association

Journal of the American Medical Informatics Association article exploring the use of health plan quality measures specified for electronic clinical data to monitor immunizations

Having the Right Staff to Support and Maintain Quality Data

Having the Right Staff to Support and Maintain Quality Data

Issued on April 26, 2022 by CDC/NCIRD/ISD/IISSB, Public Health Informatics Institute

National Meeting Presentation | Having the Right Staff to Support and Maintain Quality Data (Please note: The presentation slides shared provided an outline of presentations given at the AIRA 2022 National Meeting and are incomplete without the accompanying...

Health Dashboards for Oklahoma: Tools to Strategize Vaccination Mobility and Improvements

Health Dashboards for Oklahoma: Tools to Strategize Vaccination Mobility and Improvements

Issued on May 3, 2024 by Oklahoma State Department of Health

National Meeting Presentation | Health Dashboards for Oklahoma: Tools to Strategize Vaccination Mobility and Improvements (Please note: The presentation slides shared provided an outline of presentations given at the AIRA 2024 National Meeting and are incom...

Health Data, Technology, and Interoperability: Patient Engagement, Information Sharing, and Public Health Interoperability (HTI-2) Proposed Rule - AIRA IIS Community Comments on HTI-2

On October 4, 2024, AIRA submitted IIS community comments on ONC's latest NPRM. These comments were collected and consolidated from across the community and reviewed by AIRA's Standards and Interoperability Steering Committee (SISC)

Health Department VFC Wastage

Issued on December 16, 2024 by TN

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Purpose: This report summarizes VFC inventory that has been marked as “wastage” (wasted, spoiled, or expired) within the previous month. Data is summarized by overall wastage by vaccine and by individual provider. Outcome: This script outputs a three-ta...

Health Information Systems' Impact on Data Quality and Use in a Global Context

National Meeting Presentation | Health Information Systems' Impact on Data Quality and Use in a Global Context

Health Insurance Claims-IIS Data Linkage for Post- Vaccination Surveillance

Health Insurance Claims-IIS Data Linkage for Post- Vaccination Surveillance

Issued on May 3, 2023 by US Food and Drug Administration

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National Meeting Presentation | Health Insurance Claims-IIS Data Linkage for Post- Vaccination Surveillance (Please note: The presentation slides shared provided an outline of presentations given at the AIRA 2023 National Meeting and are incomplete without ...

Health Level 7 Implementation Guide: Current and Future States

National Meeting Presentation | Health Level 7 Implementation Guide: Current and Future States

Health Level 7 Web Service Search Success Rates in New York City’s Citywide Immunization Registry

National Meeting Presentation | Health Level 7 Web Service Search Success Rates in New York City’s Citywide Immunization Registry

Health Plans Using QBP to Query Members for HEDIS Measures

Health Plans Using QBP to Query Members for HEDIS Measures

Issued on October 2, 2019 by AIRA

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AIRA sent out an Information Request from the Oregon Immunization Program to the membership to gather the collective expertise of the IIS community regarding health plans using QBP to query members for HEDIS measures

HEDIS Process

HEDIS Process

Issued on August 18, 2022 by AIRA

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AIRA sent out an Information Request to the membership to gather the collective expertise of the IIS community regarding Medicaid match funding

HEDIS Reporting Service Charges

HEDIS Reporting Service Charges

Issued on October 24, 2024 by AIRA

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AIRA sent out an Information Request to the membership to gather the collective expertise of the IIS community regarding HEDIS reporting service charges

HEDIS Requests

HEDIS Requests

Issued on July 10, 2018 by AIRA

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AIRA sent out an Information Request from the Mississippi State Department of Health to the membership to gather the collective expertise of the IIS community regarding HEDIS requests

Helping IIS Stakeholders Help Themselves! Driving Daily Business Processes With Self-Serve Resources

National Meeting Presentation | Helping IIS Stakeholders Help Themselves! Driving Daily Business Processes With Self-Serve Resources

Hep A and Hep B Vaccination Coverage Among High-Risk Individuals in Wisconsin

National Meeting Presentation | Hep A and Hep B Vaccination Coverage Among High-Risk Individuals in Wisconsin

Hepatitis B Immunization Trends Among Massachusetts Newborns, 2022–2025

Hepatitis B Immunization Trends Among Massachusetts Newborns, 2022–2025

Issued on April 30, 2026 by Massachusetts Immunization Program

National Meeting Presentation | Hepatitis B Immunization Trends Among Massachusetts Newborns, 2022–2025 (Please note: These presentation slides are intended as supporting materials for presentations delivered at the AIRA 2026 National Meeting and may be i...

HHS Vision for Technology Support of Health IT

HHS Vision for Technology Support of Health IT

Issued on August 13, 2019 by U.S. Department of Health and Human Services

National Meeting Presentation | HHS Vision for Technology Support of Health IT

HL7 Connections with Schools

HL7 Connections with Schools

Issued on March 11, 2026 by AIRA

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AIRA sent out an Information Request to the membership to gather the collective expertise of the IIS community regarding HL7 connections with schools

HL7 Data Quality Tool: Transformation to a General Purpose Open- Source Tool

National Meeting Presentation | HL7 Data Quality Tool: Transformation to a General Purpose Open- Source Tool

HL7 Errors at Scale: Lessons from Pennsylvania’s IIS Migration

HL7 Errors at Scale: Lessons from Pennsylvania’s IIS Migration

Issued on April 30, 2026 by Pennsylvania Department of Health

National Meeting Presentation | HL7 Errors at Scale: Lessons from Pennsylvania’s IIS Migration (Please note: These presentation slides are intended as supporting materials for presentations delivered at the AIRA 2026 National Meeting and may be incomplete...

HL7 Frequently Asked Questions

HL7 Frequently Asked Questions

Issued on December 8, 2021 by AIRA

HL7 Frequently Asked Questions – Updated December 2021 The HL7 FAQ includes guidance on topics such as patient protection indicators, timestamp format, and messaging immunities. The FAQ has been reformatted for ease of use.

HL7 Timeliness and Completeness in the Michigan Care Improvement Registry (MCIR)

National Meeting Presentation | HL7 Timeliness and Completeness in the Michigan Care Improvement Registry (MCIR)

HL7 v2.5.1 Acknowledgment (ACK) Messages and their Role in Ensuring Immunization Interoperability

Objective This on-demand eLearning is designed to strengthen the IIS community’s knowledge and skills in using ACK messages to facilitate immunization data interoperability across systems, in alignment with the National IG. Learning Objectives Upon...

HL7 v2.5.1 Immunization Update (VXU) Messages Course

Objective This on-demand eLearning is designed to enhance the knowledge and skills of the IIS community in using VXU messages to support the interoperability of immunization information between systems in alignment with the National IG. Learning Object...

Dated Immunization IG, no longer in use. Use only for reference

Dated Immunization IG, no longer in use. Use only for reference

Dated Immunization IG, no longer in use. Use only for reference

Dated Immunization IG, no longer in use. Use only for reference

Health Level Seven (HL7) is a nationally recognized standard for electronic data exchange between systems housing health care data. The HL7 standard is a key factor that supports this two-way exchange of information because it defines a syntax or grammar for f...

Health Level Seven (HL7) is a nationally recognized standard for electronic data exchange between systems housing health care data. The HL7 standard is a key factor that supports this two-way exchange of information because it defines a syntax or grammar for f...

This addendum consolidates the Implementation Guide information that clarifies the conformance requirements. This supplement does not specify additional requirements; it just clarifies existing ones. Value set requirements, general clarifications, and Immuniza...